NCT00378859

The Effect of Milk and Meat on IGFs in Prepubertal Boys

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (planned)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: Male
• Age: 8 Years – 8 Years
• Healthy volunteers: Accepted

Summary

The objective of the study is to examine whether a 7-day high protein intake from either milk or meat in healthy, prepubertal children can increase fasting levels of serum IGF-I, IGFBP-3 and IGF-I/IGFBP-3 as well as insulin, glucose and HOMA insulin reststance, HOMA beta cell function and amino acids.

Detailed description

The objective of the study is to examine whether a high protein intake (PI) from either milk or meat, at a level often seen in late infancy, in healthy, prepubertal children can increase fasting levels of serum IGF-I, IGFBP-3 and IGF-I/IGFBP-3 as well as insulin, glucose and HOMA insulin reststance, HOMA beta cell function and amino acids. IGF-I levels are positively associated with growth velocity in children and some studies suggest that a high animal PI can stimulate growth. During protein deprivation IGF-I decrease, but it is unknown whether a high PI can increase s-IGF-I in well-nourished children. Insulin is also a growth factor, and studies have found that postprandially, milk possess some insulinotrophic effect not related to its carbohydrate content. However, the effect on fasting insulin in children is unknown. Design: Twenty-four 8-y-old boys are asked to take either 1.5 l of skimmed milk (n=12) or the same amount of protein as 250 g low fat meat (n=12) daily for seven days. The remaining diet they can choose freely. At baseline and after seven days, anthropometrical variables are measured, diet is registered (3-d weighed records), and the blood analytes are determined after fast.

Conditions

• Growth Disorders
• Metabolic Syndrome

Interventions

Type	Name	Description
BEHAVIORAL	Skim milk
BEHAVIORAL	Lean meat

Timeline

• Start date: 2000-11-01
• Completion: 2001-03-01
• First posted: 2006-09-21
• Last updated: 2009-01-21

Locations

1 site across 1 country: Denmark