NCT00378469

Study of the Effects of Muscular Activity on Iron Metabolism

Study of the Effects of Muscular Activity on Iron Metabolism: A Pilot Study on Healthy Volunteers

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (estimated)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and urine and blood samples will be collected regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.

Detailed description

Hemojuvelin has been described as interfering with hepcidin, a key regulator of iron homeostasis. Hemojuvelin is mainly produced by muscle, and the relationship between exercise and iron metabolism can be questioned about. The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will be investigated at two periods according to a cross-over design after: 1. 45 minutes of exercise on the ergocycle; and 2. no physical exercise. Urine and blood samples will be collected at both periods regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.

Conditions

• Iron Overload
• Iron Deficiency

Interventions

Type	Name	Description
BEHAVIORAL	45 minute exercise on ergocycle

Timeline

• Start date: 2006-09-01
• First posted: 2006-09-20
• Last updated: 2007-07-12

Locations

2 sites across 1 country: France