NCT00375375

Effect of Lactulose on Minimal Hepatic Encephalopathy and Health-Related Quality of Life

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (planned)
• Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Minimal hepatic encephalopathy (MHE) has a negative effect on patients' daily functioning. No study has so far investigated the effect of treatment related improvement in cognitive functions on health related quality-of-life (HRQOL). This study was carried out to determine the influence of treatment on psychomotor performance and on HRQOL in patients with MHE. The mean number of abnormal NP tests decreased significantly in patients in treated group compared with patients in untreated group MANOVA for time and treatment, P =.001). Mean total SIP score improved among patients in the treated group after 3 months compared with patients in untreated group after 3 months (MANOVA for time and treatment, P=.002). Improvement in HRQOL was related to the improvement in psychometry. In conclusion, treatment with lactulose improves both cognitive functions and HRQOL in cirrhotic patients with MHE.

Detailed description

The study has been published in March 2007 in Hepatology Lactulose Improves Cognitive Functions and Health-Related Quality of Life in Patients with Cirrhosis WhoHave Minimal Hepatic Encephalopathy.Srinivasa Prasad, Radha K. Dhiman, Ajay Duseja, Yogesh K. Chawla, Arpita Sharma, and Ritesh Agarwal. (HEPATOLOGY 2007;45:549-559.)

Conditions

• Minimal Hepatic Encephalopathy
• Hepatic Encephalopathy

Interventions

Type	Name	Description
DRUG	Lactulose

Timeline

• Start date: 2004-01-01
• Completion: 2004-12-01
• First posted: 2006-09-13
• Last updated: 2007-03-02

Locations

1 site across 1 country: India