NCT00372099

Bone Microstructure in Nasal Salmon Calcitonin Treated Postmenopausal Women

Evaluation of the Effects of Salmon Calcitonin Nasal Spray Compared to Placebo on Bone Microarchitecture Measured by High Resolution Peripheral Micro- Computed-tomography Over 2 Years in Postmenopausal Women (a Pilot Study)

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Rene Rizzoli · Academic / Other
• Sex: Female
• Age: 45 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Calcitonin has been used for many years for treating osteoporosis in postmenopausal women. Recent data from the 2 years placebo-controlled QUEST study have shown a preservation of microarchitecture as measured by high resolution MRI in postmenopausal women with prevalent vertebral fractures at baseline.This pilot study should provide additional new insights in the mode of action of nasal calcitonin, on structural changes as measured by high resolution peripheral CT, and on the comparison between weight bearing and non weight bearing bones in postmenopausal women.

Conditions

• Postmenopause

Interventions

Type	Name	Description
DRUG	Salmon calcitonin	nasal salmon calcitonin 200UI/day during 2 years

Timeline

• Start date: 2007-01-01
• Primary completion: 2011-10-01
• Completion: 2011-11-01
• First posted: 2006-09-06
• Last updated: 2011-12-23