NCT00370240

Chlorhydrate of Ropivacaine and Breast Cancer Surgery

Efficacy of Infiltration of Chlorhydrate of Ropivacaine in the Prevention of Chronic Breast Pain After Surgery for Breast Cancer.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 260 (actual)
• Sponsor: Institut Curie · Academic / Other
• Sex: Female
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to evaluate the effect of local anesthetic (chlorhydrate of ropivacaine) to prevent chronic pain after breast surgery for cancer.

Detailed description

An estimated 20-65% of women treated with breast surgery for breast cancer experience chronic pain in the treated breast. Patients will be randomize between: infiltration with chlorhydrate of ropivacaine at the time of breast surgery for cancer versus placebo.Intra-operative analgesia will be standardized as well as peri-operative pain management.

Conditions

• Breast Neoplasms
• Pain,Postoperative

Interventions

Type	Name	Description
DRUG	Chlorhydrate de Ropivacaine	The Ropivacaïne group received 3mg/kg of 0.375% ropivacaïne(0.75% ropivacaïne, Astra, mixed with saline)
OTHER	placebo	The PCB group received saline solution in equal volume.

Timeline

• Start date: 2006-09-01
• Primary completion: 2007-07-01
• Completion: 2008-11-01
• First posted: 2006-08-31
• Last updated: 2025-09-22

Locations

1 site across 1 country: France