NCT00363038

Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to assess the comparative utility of topical formulations in hastening the resolution of skin bruising. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser. Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0.3% retinol, 20% arnica or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist rated bruises in standardized photographs immediately after bruise creation and at week 2.

Conditions

• Ecchymosis

Interventions

Type	Name	Description
DRUG	Petrolatum United States Pharmacopeia (USP)	Topical formation applied to bruise twice daily for 2 weeks.
DRUG	Vitamin K and retinol ointment	Topical formation applied to bruise twice daily for 2 weeks.
DRUG	Arnica ointment	Topical formation applied to bruise twice daily for 2 weeks.
DRUG	Vitamin K ointment	Topical formation applied to bruise twice daily for 2 weeks.

Timeline

• Start date: 2006-07-01
• Primary completion: 2006-08-01
• Completion: 2006-08-01
• First posted: 2006-08-15
• Last updated: 2021-12-03
• Results posted: 2012-12-04

Locations

1 site across 1 country: United States