NCT00358202

Cefepime vs. Ceftriaxone to Treat Nursing Home-Acquired Pneumonia

Phase 4 Study of Once-Daily Intramuscular Cefepime Versus Ceftriaxone for In-Home Treatment of Nursing Home-Acquired Pneumonia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 69 (actual)
• Sponsor: CPL Associates · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

Randomized trial of nursing home residents with pneumonia to assess if intramuscular cefepime is a safe, efficacious, and cost-effective alternative to once daily intramuscular ceftriaxone for the treatment of elderly nursing home residents who develop pneumonia and do not require hospitalization.

Detailed description

To compare the efficacy, safety, and pharmacoeconomics of cefepime versus ceftriaxone. Double-blind study of nursing home residents \>60 years of age with pneumonia. Patients were randomized to cefepime or ceftriaxone 1 gm q24h to be administered intramuscularly. After three days, responding patients could be switched to oral antibiotics. Main Outcome Measures: clinical success, adverse events, and cost-effectiveness ratios.

Conditions

• Pneumonia

Interventions

Type	Name	Description
DRUG	cefepime	cefepime hydrochloride 1gm IM q24h
DRUG	ceftriaxone	ceftriaxone 1 gm IM q24h

Timeline

• Start date: 2002-03-01
• Completion: 2006-04-01
• First posted: 2006-07-31
• Last updated: 2007-10-31

Locations

1 site across 1 country: United States