NCT00356629

Development of a Noninvasive Method of Evaluation of Pulmonary Inflammation in the Condensates of Exhaled Air

Development of a Noninvasive Method of Evaluation of the Pulmonary Inflammation in the Condensates of Exhaled Air

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: University Hospital, Tours · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is identify biological parameters reflecting proteolytic activity in the exhaled condenstaes which might be useful to follow up pulmonary inflammation in various conditions including cystic fibrosis, COPD, asthma, tobacco exposure. Three proteases will be analyzed, i.e. elastase, proteinase 3 and cathepsin G. Results in the condensates will be compared to those obtained in sputum.

Detailed description

5 groups of 20 individuals each: group 1 CF, group 2 COPD, group 3 asthma, group 4 tobacco exposure, group 5 control subjects. Collection of exhaled condensates in all subjects and of sputum in subjects belonging to groups 1 and 2. Clinical examination and PFTs in all patients.

Conditions

• Bronchopulmonary Ignition
• Condensate of Exhaled Air
• Mucoviscidosis
• Asthma

Timeline

• Start date: 2006-07-01
• Completion: 2008-07-01
• First posted: 2006-07-26
• Last updated: 2008-11-14

Locations

1 site across 1 country: France