NCT00356135

Effect of Prasugrel on Platelets After One Week in Patients Already Taking Clopidogrel After a Cardiac Event

A Pharmacodynamic Comparison of Prasugrel (LY640315) Versus Clopidogrel in Subjects With Acute Coronary Syndrome Who Are Receiving Clopidogrel

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 139 (actual)
• Sponsor: Eli Lilly and Company · Industry
• Sex: All
• Age: 18 Years – 74 Years
• Healthy volunteers: Not accepted

Summary

This study will compare the effect of a prasugrel 10-mg maintenance dose with a clopidogrel 75-mg maintenance dose on platelet activity, approximately 1 week after the first dose of study drug, in subjects who have been taking clopidogrel 75 mg daily following a percutaneous coronary intervention (PCI) with placement of a stent, performed to treat acute coronary syndrome (ACS).

Conditions

• Coronary Arteriosclerosis
• Acute Coronary Syndrome

Interventions

Type	Name	Description
DRUG	prasugrel 10 mg	10 mg tablet taken orally
DRUG	clopidogrel	75 mg tablet taken orally
DRUG	prasugrel placebo	oral, as blinding mechanism.
DRUG	prasugrel 60 mg	60 mg (six 10-mg tablets) taken orally
DRUG	clopidogrel placebo	oral, as blinding mechanism

Timeline

• Start date: 2006-07-01
• Primary completion: 2008-12-01
• Completion: 2008-12-01
• First posted: 2006-07-25
• Last updated: 2010-11-03
• Results posted: 2010-03-09

Locations

9 sites across 1 country: United States