NCT00355498

Amyloid Plaque and Tangle Imaging in Aging and Dementia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 170 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 30 Years
• Healthy volunteers: Accepted

Summary

Amyloid senile plaques (SPs) and neurofibrillary tangles (NFTs) are neuropathological hallmarks of Alzheimer's disease (AD) that also accumulate in key brain regions in association with normal aging. This project will expand an established program in early detection and prevention of AD designed (1) to identify presymptomatic persons most likely to benefit from early intervention and (2) to provide an objective, noninvasive means to monitor therapeutic trials.

Detailed description

A total of 165 volunteers will be recruited for this 2-year study. Participants will receive a baseline clinical and imaging evaluation and one follow-up evaluation two years later. These evaluations will include clinical and neuropsychological assessments, structural MRI and/or PET scans. Additional scans and scanning procedures will be performed on a subset of participants and participant visits, including serotonin density levels.

Conditions

• Memory Disorders
• Alzheimer's Disease

Timeline

• Start date: 2005-09-01
• Primary completion: 2010-05-01
• Completion: 2010-05-01
• First posted: 2006-07-24
• Last updated: 2020-05-06

Locations

1 site across 1 country: United States