Trials / Completed
CompletedNCT00353535
Total Lymphoid Irradiation (TLI) to Prevent Focal Segmental Glomerulosclerosis (FSGS)Recurrence in the Renal Graft
Phase 1 Study of TLI Pretransplant to Prevent Recurrence of FSGS in the Graft
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 10 (planned)
- Sponsor
- University of Sao Paulo · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose was study the immunosuppression using total lymphoid irradiation plus Csa, MMF and prednisone pretransplant to prevent focal segmental glomerulosclerosis recurrence in the renal graft
Detailed description
Focal and segmental glomerulosclerosis (FSGS) is resistant to treatment with immunosuppressants and after transplant, 40% of such patients have recurrences in renal allograft. The purpose of this trial was to use Total Lymphoid Irradiation (TLI) plus mycophenolate mofetil (MMF), cyclosporine A (CsA) and prednisone (PRED) to prevent recurrence.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Total Lymphoid irradiation |
Timeline
- Start date
- 2000-01-01
- Completion
- 2002-12-01
- First posted
- 2006-07-18
- Last updated
- 2006-07-18
Locations
1 site across 1 country: Brazil
Source: ClinicalTrials.gov record NCT00353535. Inclusion in this directory is not an endorsement.