NCT00350870

CBT With Disulfiram and Contingency Management

Maximizing the Efficacy of Cognitive Behavioral Therapy With Medication and Contingency Management

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 181 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).

Detailed description

This study will compare four types of treatment involving skills training and incentives for attending sessions or taking study medication. Disulfiram is a widely prescribed deterrent to alcohol use. In addition to weekly cognitive behavioral therapy (CBT), participants will be assigned to one of the following treatments: 1. placebo 2. disulfiram 3. placebo plus incentives for cocaine abstinence and medication compliance (prize CM) 4. disulfiram plus incentives for cocaine abstinence and medication compliance

Conditions

• Cocaine Abuse

Interventions

Type	Name	Description
DRUG	disulfiram	250mg per day of Disulfiram plus CBT
DRUG	Placebo	Placebo plus CBT
BEHAVIORAL	Placebo plus Contingency Management	Placebo plus Contingency Management for cocaine abstinence and medication compliance in addition to CBT
DRUG	Disulfiram plus Contingency Management	250mg of Disulfiram plus Contingency Management for cocaine abstinence and medication compliance plus CBT.

Timeline

• Start date: 2005-04-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2006-07-11
• Last updated: 2014-12-03
• Results posted: 2014-12-03

Locations

1 site across 1 country: United States