NCT00350077

The Effect of High Dose Vitamin C in Burn Patients

The Effect of High Dose Versus Low Dose Intravenous Vitamin C (Ascorbic Acid)on Burn Injury Resuscitation

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: United States Army Institute of Surgical Research · Federal
• Sex: All
• Age: 18 Years – 72 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to see if intravenous Vitamin C will decrease the amount of IV fluids needed following burn injury in the first 48 hours.

Detailed description

Adequate fluid resuscitation in burn injured patients to allow adequate renal blood flow has been the hallmark of burn care in the last 50 years. The danger of exceeding the optimal intravenous fluid resuscitation has resulted in severe complications including abdominal compartment syndrome, loss of upper airway control, extremity compartment syndromes and pulmonary edema. Hig dose vitamin C infusion during the first 24 hours of burn resuscitation has been documented to decrease the overall amount of intravenous fluid needed to provide for adequate renal perfusion and hemodynamic stability in multiple animal model studies. High dose vitamin C is thought to decrease postburn microvascular protein and fluid leakage by reducing postburn lipid oxygenation caused by burn injury generated free radicals.

Conditions

• Burns

Interventions

Type	Name	Description
DRUG	Intravenous Vitamin C	vitamin C IV during 24 hour period following burn
DRUG	Vitamin C	IV vitamin C

Timeline

• Start date: 2006-07-01
• Primary completion: 2008-03-01
• Completion: 2008-03-01
• First posted: 2006-07-10
• Last updated: 2011-12-20

Locations

1 site across 1 country: United States