NCT00348426

Botulism Outbreak in Thailand (Episode II)

Clinical Manifestations of Botulism Outbreak in Northern Thailand: A Case Series of Botulism Treated With Botulinum Anti-Toxin.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (planned)
• Sponsor: Department of Medical Services Ministry of Public Health of Thailand · Other Government
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

A second botulism outbreak in Northern Thailand was reported in 2006. 192 people were exposed to raw meat and the gut of deer, 83 suffered from diarrhea. Of these 5 developed respiratory failure, 1 impending respiratory failure. We analysed the clinical findings and electrophysiologic findings in this second episode of large botulism outbreak in northern Thailand.

Detailed description

PRELIMINARY REPORT Northern Thailand's big botulism outbreak occurred again on 30 June 14, 2006, \[16.00pm\] affecting 83 from 192 people who exposed to raw dear meat and gut \[1 night preserved with ice pack of whole body of dear before disection and distribution \]. Of these, 3 developed respiratory failure, 1 developed impending respiratory failure, 83 of 192 whom developed fatique and diarrhea after ingestion of raw dear meat and gut on 26-30 June 2006. 3 patients were refered to 2 high facility hospitals for severe respiratory failure. Physical examination of 3 patients in ICU of Chiang Kum general hospital revealed ptosis \[3/3\] mild ophthalmoparesis \[2/3\] Proximal muscle weakness \[2/3\] abdominal paradoxical respiration \[3/3\] pupil dilate \[1/3\] and negative inspiratory pressure \[NIP\] less than 15 mmHg \[3/3\] were observed. Neurological electrophysiologic study of 2 patients revealed low amplitude compound muscle action potential \[CMAP\] of Abductor digiti minimi \[ADM\] muscle with decrement response after repetitive stimulation with low frequency \[3Hz\], increment response of ADM muscle after stimulation with high frequency \[10Hz, 20Hz, and 30Hz.\].The electrophysiologic findings support diagnosis of presynaptic neuromuscular dysfunction with respiratory failure, Botulism is most likely diagnosis. After treated with botulinum antitoxin \[on July,1 ,2006 \[mixed-type botulinum antitoxin --donated from Japan at Nan Hospital's botulisum outbreak on March 14,2006\], 3 patients in ICU showed improvement of over all clinical outcomes. Active survey by Ministry of Public Health of Thailand and CDC-USA to identify the high risk patient who may develop respiratory failure , and immunologucal vs microbiological diagnosis were performed. This outbreak may be the second hit of botulisum in the northern Thailand but less amount of severe cases was observed.

Conditions

• Botulism

Interventions

Type	Name	Description
DRUG	Botulinum AntiToxin
PROCEDURE	neuro-electrophysiologic study, repetitive nerve stimulation
PROCEDURE	: Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure

Timeline

• Start date: 2006-06-01
• Completion: 2006-09-01
• First posted: 2006-07-04
• Last updated: 2006-11-08

Locations

1 site across 1 country: Thailand