NCT00347178

Asymptomatic Narrow Angles - Laser Iridotomy Study; Multicentric RCT

Prophylactic Laser Iridotomy for Eyes With Narrow Drainage Angles; A Randomised Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 544 (planned)
• Sponsor: Singapore National Eye Centre · Other Government
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

This is a multicentric, randomised, controlled study comparing Laser Iridotomy (LI) to no treatment in subjects with asymptomatic narrow angles (ANA).One eye of each subject with ANA will be randomised to undergo LI and the other eye will be left alone and will serve as an internal control. Subjects are proposed to be followed up once a year for 5 years.

Detailed description

Objective: This study will compare LI versus no treatment in subjects with asymptomatic narrow angles, the anatomical trait that predisposes to primary angle closure glaucoma (PACG), in order to assess the effectiveness of prophylactic treatment in the prevention of blindness due to PACG. Eligibility: 1. Bilateral Narrow angles; 2. Age 50 years and above; 3. Informed consent obtained prior to or at baseline visit. Trial Design: Subjects with asymptomatic ANA undergoes randomisation after comprehensive ocular exam followed by randomisation to LI in one eye and no treatment in the other eye. Follow up is done for 5 years with yearly examination.

Conditions

• Asymptomatic Narrow Angles
• Primary Angle Closure Suspects

Interventions

Type	Name	Description
PROCEDURE	Laser Peripheral Iridotomy

Timeline

• Start date: 2005-01-01
• Completion: 2013-01-01
• First posted: 2006-07-04
• Last updated: 2006-07-04

Locations

1 site across 1 country: Singapore