NCT00345943

An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 71 (actual)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: Female
• Age: 12 Years – 17 Years
• Healthy volunteers: Accepted

Summary

The aim of this project is to use both multimodal MRI and behavioral measures to investigate how changes in frontostriatal neural systems contribute to the development and persistence of Bulimia Nervosa (BN). Findings from this study will have wide-ranging importance for our understanding of the development and treatment of BN.

Detailed description

Patients with Bulimia Nervosa (BN) have difficulty regulating impulsive behaviors as suggested by their binge-eating and purging, as well as the high incidence of drug abuse and shoplifting in this population. Understanding dysfunction in the frontostriatal circuitry that mediates self-regulatory control processes will aid development of new therapeutics for the impulsivity associated with BN. We are conducting a longitudinal study to better understand the development and persistence of BN. Participation in this study includes 4 sections: Neuropsychological Tests, Diagnostic interviews, Pregnancy Test, and MRI scan. All efforts are made to coordinate procedures into one day, and they require between 4 and 5 hours of the participant's time. The option of splitting participation into two study days is also offered for participants who find it more convenient. Participants are compensated with $100 in the form of a check, which is mailed to their home address. Participants will be invited back for follow-up visits.

Conditions

• Eating Disorders

Interventions

Type	Name	Description
OTHER	MRI	Magnetic Resonance Imaging scans
BEHAVIORAL	Neuropsychological Testing	Neuropsychological tests

Timeline

• Start date: 2004-10-01
• Primary completion: 2016-09-01
• Completion: 2021-08-01
• First posted: 2006-06-29
• Last updated: 2021-12-02
• Results posted: 2021-12-02

Locations

1 site across 1 country: United States