NCT00345150

Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls

Phase 1 Study of the Effects of Systemic Nitric Oxide Inhibition With Ng-Monomethyl-L-Arginine on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (planned)
• Sponsor: Regional Hospital Holstebro · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The study tests the hypothesis that systemic and renal nitric oxide synthesis is changed in essential hypertension by investigating the effects of a non selective nitric oxide inhibitor on renal hemodynamics and sodium excretion in patients with essential hypertension. The results are compared with a group of healthy subjects.

Detailed description

The study investigates the effects of Ng-monomethyl-L-arginine (L-NMMA) on: 1. renal hemodynamics (renal plasma flow and glomerular filtration rate) 2. renal sodium excretion 3. lithium clearance and fractional lithium excretion 4. plasma levels of vasoactive hormones 5. blood pressure and heart rate

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Ng-monomethyl-L-arginine (drug)

Timeline

• First posted: 2006-06-27
• Last updated: 2006-06-27