Trials / Completed
CompletedNCT00344916
Phase 1 Study of L-NMMA in Patients With Liver Cirrhosis
NO-Synthesis in Patients With Liver Cirrhosis: Effect of L-NMMA on Renal Hemodynamics, Sodium Excretion and Plasma Levels of Vasoactive Hormones
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 30 (planned)
- Sponsor
- Regional Hospital Holstebro · Academic / Other
- Sex
- All
- Age
- 20 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
Phase 1 study of the effects of nitric oxide inhibition with L-NMMA in patients with liver cirrhosis and healthy controls. It is hypothesized that nitric oxide availability is increased in liver cirrhosis.
Detailed description
In a randomized, placebo controlled design the acute effects of Ng-monomethyl-L-arginine are studied on: * renal hemodynamics (GFR and RPF) * blood pressure and heart rate * lithium clearance * plasma levels of vasoactive hormones
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Ng-monomethyl-L-arginine (drug) |
Timeline
- First posted
- 2006-06-27
- Last updated
- 2006-07-11
Source: ClinicalTrials.gov record NCT00344916. Inclusion in this directory is not an endorsement.