Trials / Completed
CompletedNCT00340392
Isolation and Characterization of Mammary Stem Cells
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 400 (estimated)
- Sponsor
- National Cancer Institute (NCI) · NIH
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Background: * Cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated. This deregulation seems to be necessary for cancer to develop. * These cells can be identified by certain surface markers that overlap with markers associated with normal embryonic stem cells. Objective: To isolate tumor stem cells using the same methods generally used to isolate human embryonic stem cells. Eligibility: * Tissue samples will be obtained from the human cooperative network. * Samples will include normal tissues from individuals who have no opportunistic diseases and from individuals with cancer. Design: Breast cancer stem cells will be isolated, grown in the laboratory and characterized.
Detailed description
Cancers are composed of heterogeneous populations of cells with varying degrees of proliferative capacity and ability to reconstitute tumors when transplanted into nude or SCID mice. Recently, cancer stem cells have been identified as a small population of tumor cells which possess the stem cell properties in that their self-renewal pathway is highly deregulated. This deregulation seems to be the prerequisite for the development of cancer.
Conditions
Timeline
- Start date
- 2006-04-07
- Completion
- 2011-03-23
- First posted
- 2006-06-21
- Last updated
- 2017-07-02
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00340392. Inclusion in this directory is not an endorsement.