NCT00336908

Inflammatory Responses to Lipid Emulsions in Children Before and After Open Heart Surgery

Inflammatory Responses of Intravenous Fish Oil, Soybean Oil and Medium Chain Triglyceride Fat Emulsions in Young Children Before and After Open Heart Surgery

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: University of Alberta · Academic / Other
• Sex: All
• Age: 3 Months
• Healthy volunteers: Not accepted

Summary

This study is a blinded, randomized, controlled prospective trial comparing immune response (sepsis, inflammatory response, pulmonary vasoconstriction) in 2 groups of infants less than 3-month old receiving pre and post cardiopulmonary bypass surgery. The infants will receive 1 out of the 2 following intravenous lipid preparations: Soybean Oil (n-6), or a combination of Medium Chain Triglyceride i.e. coconut oil, Long Chain Triglyceride i.e. Soybean Oil, and Fish Oil (MCT:LCT:FO). There will be 16 subjects in each group.

Conditions

• Inflammation
• Cardiac Surgical Procedures

Interventions

Type	Name	Description
DRUG	a combination of MCT, LCT , and Fish Oil

Timeline

• Start date: 2005-11-01
• Completion: 2007-11-01
• First posted: 2006-06-14
• Last updated: 2007-11-27

Locations

1 site across 1 country: Canada