Trials / Completed
CompletedNCT00336739
The Effect of Cinacalcet on Gastric Acid Output in Healthy Subjects
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 17 (actual)
- Sponsor
- Tufts University · Academic / Other
- Sex
- All
- Age
- 45 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to determine whether cinacalcet will increase gastric acid secretion in healthy volunteers.
Detailed description
The calcium sensing receptor (CaSR) was originally found on parathyroid and renal cells and more recently it has been identified on cells that regulate gastric acid secretion (G cells and parietal cells). However, its role in regulating acid secretion in humans is completely unknown and is of potential importance because an acid environment in the stomach enhances intestinal calcium absorption. In this pilot project, we will stimulate the CaSR with a CaSR-agonist called cinacalcet. Our hypothesis is that activation of the CaSR will in turn increase gastric acid production in healthy volunteers.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | cinacalcet |
Timeline
- Start date
- 2006-04-01
- Completion
- 2007-03-01
- First posted
- 2006-06-14
- Last updated
- 2007-07-23
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00336739. Inclusion in this directory is not an endorsement.