NCT00312325

Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (planned)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 19 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Because of their antiinflamatory effects, glucocorticoids are often used to reduce edema in neurologic tissue and to otherwise mitigate the consequences of neural inflammation. For example, high dose prednisolone treatment has been shown to be an effective therapy for different eye diseases including severe Graves´ Ophthalmopathy and acute optic neuritis. However, contradictory results exists for the influence of high dose prednisolone therapy per se on tissue blood flow. Thus, in the current study, we plan to investigate the effect of high dose, short time therapy with intravenous prednisolone in patients with optic neuritis and severe Graves´ Ophthalmopathy.

Conditions

• Regional Blood Flow
• Optic Disk

Interventions

Type	Name	Description
DRUG	Prednisolone

Timeline

• Start date: 2005-07-01
• Completion: 2005-08-01
• First posted: 2006-04-10
• Last updated: 2006-04-10

Locations

1 site across 1 country: Austria