NCT00311961

Intravenous Versus Oral Administration of Prednisolone in Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)

A Comparison of Intravenous Versus Oral Administration of Prednisolone in the Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 256 (planned)
• Sponsor: Isala · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: —

Summary

Treatment with systemic corticosteroids for acute exacerbations of COPD results in the improvement of clinical outcomes. The optimal route of administration has not been rigorously studied in COPD. Upon hospitalization, corticosteroids are administered intravenously in many hospitals. Oral administration is more convenient, though, because there is no need for intravenous access, less personnel is required for starting and monitoring therapy, and material costs are smaller. The investigators hypothesized that oral administration is not inferior to intravenous administration of prednisolone in the treatment of patients hospitalized for an acute exacerbation of COPD.

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
DRUG	Intravenous prednisolone
DRUG	Oral prednisolone

Timeline

• Start date: 2001-06-01
• Primary completion: 2003-08-01
• Completion: 2003-08-01
• First posted: 2006-04-07
• Last updated: 2009-08-26

Locations

1 site across 1 country: Netherlands