NCT00300911

Effects of Rosiglitazone on Plasma BNP Levels and Left Ventricular Dysfunction

A Study of PPAR-Gamma Agonist-Rosiglitazone for Determining Cardiac Adverse Effects in Type 2 Diabetic Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 45 (planned)
• Sponsor: Baskent University · Academic / Other
• Sex: All
• Age: 45 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The present study aimed to evaluate the effect of rosiglitazone treatment on cardiac function compared with metformin

Detailed description

Large scale clinical trials have reported fluid retention and increase in plasma volume (6% to 7%) with glitazone therapy, with an increased incidence of peripheral edema occuring in 2% to 5% patients. Some evidence suggests that this effect may be related to increased endothelial cell permeability induced by glitazones therapy. Others report that glitazones may interfere with renal hemodynamics. In controlled clinical trials, the frequency of new onset congestive heart failure was very low in glitazones treated patients. The incidence of congestive heart failure is higher in patients receiving combination therapy with insulin and glitazones. Only few studies compared rosiglitazone and metformin on cardiac safety. Recently a study reported a reversible increase in endothelial cell permeability to albumin in cultured pulmonary arterial cells treated with rosiglitazone. To our knowledge, there is not any clinical study published for showing the reversibility of the cardiac adverse effects if the rosiglitazone treatment is continued.

Conditions

• Diabetes Mellitus, Type 2

Interventions

Type	Name	Description
DRUG	Rosiglitazone(drug), cardiac adverse effects

Timeline

• Start date: 2005-12-01
• First posted: 2006-03-10
• Last updated: 2006-03-10

Locations

1 site across 1 country: Turkey (Türkiye)