NCT00298129

Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 278 (actual)
• Sponsor: Yokohama City University Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Many patients with chronic renal disease show a loss of the nocturnal decline of blood pressure (non-dipper). However, the mechanism is not yet fully understood. We evaluate 24-hour blood pressure in patients with chronic renal disease using an ambulatory blood pressure monitoring device (A \& D TM2425). We also analyze the power spectrum of heart rate variability as an index of autonomic cardiovascular modulation using the same device.

Detailed description

The ratio of lower frequency (LF) and higher frequency (HF) heart rate rhythmic oscillations is expressed as an index of sympathovagal balance. Patients with chronic renal disease participate in the study. Blood pressure and power spectrum of heart rate variability for 24 hours are measured when they receive no medication for at least 1 week. The mean waking and sleeping time systolic and diastolic blood pressure are calculated. LF/HF ratios in the chronic renal disease are evaluated to calculate the waking/sleeping ratio for LF/HF.

Conditions

• Diabetes Mellitus
• Essential Hypertension
• Renal Failure
• Chronic Nephropathy

Interventions

Type	Name	Description
DEVICE	Ambulatory blood pressure monitoring

Timeline

• Start date: 2004-02-01
• Completion: 2006-12-01
• First posted: 2006-03-01
• Last updated: 2007-05-09

Locations

1 site across 1 country: Japan