NCT00294606

Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery

Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Cross-Clamping During Carotid Endarterectomy Under General Anesthesia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 86 (planned)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia. The effect of the vasopressor on cardiac function will be measured using electrocardiography, transesophageal echocardiography and cardiac troponin I intraoperatively and postoperatively. We will use a cross-over pattern since both drugs exhibit rapid onset and short duration of action. We hypothesize that there will be less myocardial ischemia associated with the use of norepinephrine when compared with phenylephrine during carotid artery surgery.

Conditions

• Vasopressor Agents
• Endarterectomy, Carotid
• Echocardiography, Transesophageal

Interventions

Type	Name	Description
DRUG	Comparison of Effects of Phenylephrine and Norepinephrine

Timeline

• Start date: 2006-02-01
• Completion: 2006-02-01
• First posted: 2006-02-22
• Last updated: 2006-02-22

Locations

1 site across 1 country: Canada