NCT00292162

Curing Atrial Fibrillation in Heart Failure

Radiofrequency Ablation for Atrial Fibrillation in Advanced Chronic Heart Failure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 41 (actual)
• Sponsor: NHS Greater Glasgow and Clyde · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

Heart failure is a condition that occurs when the heart muscle weakens and no longer contracts normally. Half of these patients have an irregularity of heart rhythm called atrial fibrillation (AF). Patients with both heart failure and AF spend more time in hospital, and die earlier than those with heart failure alone. AF is difficult to treat with conventional methods in patients with heart failure. Radiofrequency ablation is a new technique used to cure AF. The investigators aim to establish if radiofrequency ablation for atrial fibrillation in patients with advanced heart failure can result in marked improvement in the function of the heart.

Conditions

• Chronic Heart Failure
• Atrial Fibrillation

Interventions

Type	Name	Description
PROCEDURE	radiofrequency ablation	isolation of the pulmonary veins with radiofrequency ablation (RFA)
DRUG	ACE inhibitor - ramipril, enalapril, captopril, perindopril, lisinopril	Evidence based treatment for heart failure. Dose and type will depend on patient tolerability.
DRUG	Beta Blocker (BB) - metoprolol, bisoprolol, carvedilol	Evidence based treatment for heart failure. Dose and type will depend on patient tolerance.
DRUG	Aldosterone Antagonists - spironolactone	Evidence based treatment for heart failure. Dose and type will depend on patient to treatment.

Timeline

• Start date: 2007-01-01
• Primary completion: 2009-07-01
• Completion: 2009-07-01
• First posted: 2006-02-15
• Last updated: 2012-06-01
• Results posted: 2012-06-01

Locations

1 site across 1 country: United Kingdom