Trials / Completed
CompletedNCT00284726
The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation
A Prospective, Controlled, Randomized Study on the Effect of Cold Storage Solutions on Complement Activation and Other Mediators of Ischemic Injury in Lung Transplantation
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- —
- Sponsor
- Johns Hopkins University · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- —
Summary
The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.
Detailed description
The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Celsior Cold Storage Solution |
Timeline
- Start date
- 2000-12-01
- Completion
- 2005-09-01
- First posted
- 2006-02-01
- Last updated
- 2023-09-28
Source: ClinicalTrials.gov record NCT00284726. Inclusion in this directory is not an endorsement.