NCT00276952

Gonyautoxin in the Treatment of Chronic Tension-Type Headache

Phase 2 Study of Treatment of Chronic Tension-Type Headache Using Gonyautoxins

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 27 (planned)
• Sponsor: University of Chile · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the clinical efficacy of Gonyautoxin 2/3 epimers in the treatment of patients diagnosed with chronic tensional-type headache in accordance with International Headache Society guidelines

Detailed description

Gonyautoxin are phycotoxins, whose molecular mechanism of action is a reversible block of the voltage-gated sodium channels at neuronal level. They are axonal conduction blockers impeding nerve impulse propagation. In order to evaluate the clinical efficacy of Gonyautoxin 2/3 epimers in the treatment of patients diagnosed with chronic tensional-type headache, the patients were locally injected with placebo versus Gonyautoxin following a painful spots injection standarized protocol

Conditions

• Tension-Type Headache

Interventions

Type	Name	Description
DRUG	Gonyautoxin

Timeline

• Start date: 2004-09-01
• Completion: 2005-08-01
• First posted: 2006-01-13
• Last updated: 2006-01-13

Locations

1 site across 1 country: Chile