NCT00275496

Multicenter Selective Lymphadenectomy Trial (MSLT)

A Clinical Study of Wide Excision Alone Versus Wide Excision With Intraoperative Lymphatic Mapping and Selective Lymph Node Dissection in the Treatment of Patients With Cutaneous Invasive Melanoma.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 2,001 (actual)
• Sponsor: Saint John's Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Subjects must be diagnosed with melanoma. All subjects receive Wide Excision (WEX) of their melanoma. If the melanoma meets study requirements, the subject is randomized to receive either (1) no further surgical procedures as part of the study or (2) a Selective Lymphadenectomy with the possibility of a Complete Lymphadenectomy. Subjects are then followed for 10 years.

Conditions

• Melanoma

Interventions

Type	Name	Description
PROCEDURE	Sentinel Lymph Node Dissection	Subject has wide excision and sentinel lymph node dissection for primary melanoma.
PROCEDURE	Complete Lymph Node Dissection	Subject has wide excision, sentinel lymph node dissection, and complete lymph node dissection (if positive sentinel node found) for primary melanoma.
PROCEDURE	Wide Excision	Subject has wide excision only for primary melanoma.

Timeline

• Start date: 1993-11-01
• Primary completion: 2012-06-01
• Completion: 2012-06-01
• First posted: 2006-01-12
• Last updated: 2015-09-02