NCT00275405

Effect of Garlic on Inflammatory Mediators

Effect of Garlic Oil Macerate on Inflammatory Mediators in Healthy Normal Weight and Obese Subjects.

• Status: Suspended
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 34 (planned)
• Sponsor: Albany Medical College · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This research will investigate the effect of garlic oil extract when added to daily diet on inflammatory mediators and blood clotting activation.

Detailed description

To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Garlic Oil Macerate

Timeline

• Start date: 2006-04-01
• Completion: 2007-03-01
• First posted: 2006-01-12
• Last updated: 2007-03-20

Locations

1 site across 1 country: United States