NCT00274430

Prevention of High Altitude Pulmonary Edema

A Randomized Controlled Trial of the Effects of Tadalafil and Dexamethasone Versus Placebo on Pulmonary Edema Formation and Cerebral Blood Flow Autoregulation in High Altitude Newcomers With a Previous History of High Altitude Pulmonary Edema

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 30 (planned)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

A double-blind placebo controlled study * To compare the effect of tadalafil and dexamethasone versus placebo on Ppa and pulmonary edema formation in subjects susceptible to HAPE. * To investigate the effect of dexamethasone on alveolar fluid clearance, as assessed by measurement of the nasal potential difference, and prevention of HAPE. * To investigate the effect of the tadalafil and dexamethasone versus placebo on the dynamic CBF autoregulation properties and on the development of AMS in HAPE susceptible subjects.

Conditions

• High Altitude Pulmonary Edema

Interventions

Type	Name	Description
DRUG	dexamethasone 8 mg bid
DRUG	tadalafil 10mg bid

Timeline

• Start date: 2003-07-01
• Completion: 2003-09-01
• First posted: 2006-01-10
• Last updated: 2006-12-04