Trials / Completed
CompletedNCT00274209
Chromoendoscopy for Ulcerative Colitis Surveillance
Impact of Chromoendoscopy on the Detection of Neoplasia in Ulcerative Colitis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (actual)
- Sponsor
- Indiana University School of Medicine · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Long-standing ulcerative colitis is associated with an increased cancer risk. Chromoendoscopy with dye spraying can detect subtle abnormalities that are not visible with standard endoscopy. The purpose of this study is to determine if chromoendoscopy with fewer "targeted biopsies" can replace standard colonoscopy with multiple "random" biopsies.
Detailed description
Patients with ulcerative colitis (UC) are at increased risk for colon cancer. Current guidelines recommend periodic surveillance colonoscopy in individuals who fulfill certain high-risk criteria. Endoscopists must perform a high number of biopsies (over 33 per patient) in order to increase the yield of such procedures. Chromoendoscopy (CE) has the ability to identify subtle lesions that are otherwise missed by standard endoscopy. Whether CE can replace standard colonoscopy in the surveillance of patients with UC is unknown. Comparison: both standard biopsies and targeted biopsies will be obtained during colonoscopy from patients with UC who are candidates for surveillance colonoscopy. The yield of the two methods will be compared based on the number of biopsies required to identify one dysplastic (precancerous) lesion.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Chromoendoscopy with magnification | A blue dye (indigo carmine) will be sprayed prior to imaging the bowel lining using a zoom colonoscope. The dye is not absorbed and is safe for human use. |
Timeline
- Start date
- 2005-12-01
- Primary completion
- 2011-11-01
- Completion
- 2011-11-01
- First posted
- 2006-01-10
- Last updated
- 2011-11-22
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00274209. Inclusion in this directory is not an endorsement.