NCT00273065

Local Anesthetic Properties of Neosaxitoxin

Phase 1 Study of Local Infiltration of Neosaxitoxin as a Local Anesthetic

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 10 (planned)
• Sponsor: University of Chile · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the local anesthetic properties of neosaxitoxin in humans

Detailed description

Neosaxitoxin is a phycotoxins that reversible block the voltage-gated sodium channels at neuronal level. Its activity is express as blocking the axonal conduction, stopping the propagation of the nerve impulse. The objective of the present work is to evaluate the neosaxitoxin efficacy and safety as local anesthetic in a human trial Methods: Randomized, double-blind, placebo-controlled trial, with 10 healthy volunteers. The anesthetic effect will be evaluated using a standardized human sensory and pain model. TSA Neurosensory analyser and Von Frey Technique will be used to evaluate five parameters: sensory threshold for warm and cold, pain thresholds for heat and cold and mechanical touch perception threshold.

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
DRUG	Neosaxitoxin

Timeline

• Start date: 2005-05-01
• Completion: 2005-09-01
• First posted: 2006-01-09
• Last updated: 2007-02-19

Locations

1 site across 1 country: Chile