NCT00264407

Neural Changes in the Aging Auditory System

Age-Related Hearing Loss: Presbycusis & Its Neural Bases

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 126 (planned)
• Sponsor: University of Rochester · Academic / Other
• Sex: Female
• Age: 60 Years – 86 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.

Detailed description

Background: Female hormone influences on the development and aging of the auditory system are not completely understood. The present study retrospectively analyzed and compared hearing abilities among post-menopausal women taking hormone replacement therapy (HRT), treated with estrogen and progesterone (E+P); estrogen alone (E), and a third (control - NHRT) group, matched for age, who did not receive any HRT. Methods: 126 subjects, (60-86 yr), N=32, E+P; N=31, E; N= 63, NHRT; matched for age and health status participated. All had relatively healthy medical histories, absence of significant noise exposure, middle ear problems, major surgeries or current/heavy smoking. Hearing tests included pure tone audiometry (PTA), tympanometry, distortion-product otoacoustic emissions (DPOAEs), transient otoacoustic emissions (TEOAEs) and hearing-in-noise-test (HINT). The latter is a test for speech perception in background noise: the major complaint of hearing-impaired persons. .

Conditions

• Progesterone
• Estrogens
• Hearing
• Psychoacoustics
• Auditory Perceptual Disorders

Interventions

Type	Name	Description
DRUG	Hormone Replacement Therapy - HRT

Timeline

• Start date: 2001-01-01
• Completion: 2005-02-01
• First posted: 2005-12-12
• Last updated: 2005-12-12

Locations

2 sites across 1 country: United States