NCT00264368

Ganciclovir Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 6 (estimated)
• Sponsor: University of Oslo School of Pharmacy · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In order to optimize anti-cytomegalovirus (CMV) treatment with ganciclovir (GCV), in patients with multi organ failure treated with continuous renal replacement therapy (RRT), more information about ganciclovir pharmacokinetics in this setting is needed. The primary objective is to describe the pharmacokinetics of ganciclovir in critically ill patients with acute renal failure treated with continuous renal replacement therapy, with a special emphasis on the extra-renal clearance and distribution volume. Secondary objectives are to investigate if any co-factors, such as serum creatinine, weight, general hydration status, rest function of the native kidneys, etc. can help to describe the pharmacokinetics of GCV in these patients on continuous RRT as well as the relative influence of filtrations and dialysis on GCV elimination during different modalities of the treatment.

Conditions

• Acute Renal Failure
• Cytomegalovirus Infections
• Multi Organ Failure

Interventions

Type	Name	Description
DRUG	intravenous (IV) ganciclovir

Timeline

• Start date: 2005-12-01
• Completion: 2007-06-01
• First posted: 2005-12-12
• Last updated: 2007-06-28

Locations

1 site across 1 country: Norway