NCT00261209

Collagenase in the Treatment of Zone II Flexor Tendon Adhesions in the Hand

Study of Collagenase Injection Therapy for Treatment of Zone II Flexor Tendon Adhesions in the Hand

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: Stony Brook University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to dissolve flexor tendon adhesions associated with failed tendon repair surgery.

Detailed description

In an open label study, collagenase injection therapy was investigated in 3 subjects for it's ability to lyse flexor tendon adhesions in zone II of the hand. Results indicate that two of three subjects had improved range of finger motion at the PIP and DIP joints. This may obviate the need for patients to have tenolysis hand surgery to correct the finger flexion contracture of the PIP and DIP joints. Detailed controlled studies remain to be done.

Conditions

• Adhesion of Flexor Tendon of Hand

Interventions

Type	Name	Description
DRUG	Collagenase	Collagenase injection into adhesion restricting tendon gliding
DRUG	Collagenase injection	injection of collagenase into adhesion restricting tendon gliding

Timeline

• Start date: 2005-01-01
• Primary completion: 2008-01-01
• Completion: 2008-01-01
• First posted: 2005-12-02
• Last updated: 2016-04-21

Locations

1 site across 1 country: United States