Trials / Completed

CompletedNCT00259246

The Role of Peptide YY (PYY)Infusions in Inhibiting Food Intake.

Fasting and Postprandial Response After Infusion of Saline, PYY1-36 and PYY3-36 and Effects on Appetite, Energy Intake and Energy Expenditure in Overweight/Obese Compared to Normalweight Subjects

Status: Completed
Phase: N/A
Study type: Interventional
Enrollment: 24 (planned)

Sponsor: University of Copenhagen · Academic / Other
Sex: Male
Age: 20 Years – 50 Years
Healthy volunteers: Accepted

Summary

The aim of the study is to compare fasting and postprandial PYY levels between overweight/obese and lean subjects during and after an infusion of saline, PYY1-36 or PYY3-36 and to evaluate the efects on appetite, energy intake and energy expenditure.

Detailed description

The study is a randomised dobbelblinded placebo controlled study with 24 male subjects ( 12 lean and 12 overweight/obese subjects). VAS scores are used to assess appetite and two ad libitum meals are served in the hours following the infusion. Energy expenditure is measured by ventilated hood system and blood is sampled during part of the study day.

Conditions

Obesity

Interventions

Type	Name	Description
DRUG	Peptide YY infusion

Timeline

Start date: 2004-06-01
Completion: 2005-11-01
First posted: 2005-11-29
Last updated: 2009-01-21

Source: ClinicalTrials.gov record NCT00259246. Inclusion in this directory is not an endorsement.