NCT00253006

Analysis of Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium

A Quantitative Analysis of Protein- and mRNA-Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 60 (planned)
• Sponsor: Copenhagen University Hospital at Herlev · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Painful bladder syndrome (PBS)/interstitial cystitis (IC) may be due to the actions of nitric oxide (NO) in the bladder tissue. NO is a gaseous substance with a very short half-life, synthesized by a group of NO-synthase-enzymes in many tissues. The goal of this study is to illuminate bladder tissue production of NO in individuals with PBS and healthy individuals, by quantification of NO and NO-enzyme expression by different molecular biological methods.

Conditions

• Interstitial Cystitis
• Bladder Diseases
• Urinary Incontinence

Interventions

Type	Name	Description
PROCEDURE	Tissue examination for protein- and mRNA-expression of NO

Timeline

• Start date: 2006-01-01
• Completion: 2008-01-01
• First posted: 2005-11-15
• Last updated: 2006-10-09

Locations

1 site across 1 country: Denmark