NCT00248885

Peri-Operative Morbidity and Quality of Life After Coronary Artery Bypass Graft (CABG)

Peri-Operative Morbidity and Quality of Life After CABG

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 248 (actual)
• Sponsor: Weill Medical College of Cornell University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

It is the long term objective of this study to preserve or improve the quality of life and to prevent deterioration in physical and mental function following myocardial revascularization among bypass surgery patients.

Detailed description

The objective of this study is to compare the efficacy of two strategies of intra-operative hemodynamic management in preventing peri-operative cardiac, cognitive and neurologic morbidity and mortality and postoperative deterioration in the patient's quality of life.

Conditions

• Coronary Artery Bypass Graft Surgery

Interventions

Type	Name	Description
PROCEDURE	Regulating Mean Arterial Pressure during cardiopulmonary bypass	Patients were randomized to one of two groups. In the first group (Low) the goal was to maintain MAP between 50-60 mm Hg during CPB. In the second group (High), the goal was to maintain MAP between 80-100 mm Hg. In both groups, CPB flow was held constant at 1.6 L/min/M2 (cool) and 2.4 L/min/M2 (warm) and vasoactive drugs (nitroglycerin or phenylephrine) were used to maintain MAP in the desired range. MAP was controlled in this fashion from the onset of CPB through separation from CPB began.

Timeline

• Start date: 1991-09-01
• Completion: 1994-09-01
• First posted: 2005-11-04
• Last updated: 2008-04-11

Locations

1 site across 1 country: United States