NCT00244517

DIAFAX I+II-Effects of Inhalative Anesthetics on Left Ventricular Diastolic Function

The Effects of Remifentanil, Sevoflurane, Isoflurane and Desflurane on Left Ventricular Diastolic Function in Humans

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

Anaesthetics may impair the diastolic function of the heart, but the importance of this finding for patients has not been sufficiently examined. Specially the effects on diastolic function in patients with diastolic dysfunction has to be determined. The aim of this study is to examine the effect of isoflurane (only part I), sevoflurane and desflurane (part I+II) on the diastolic left ventricular function by doppler echocardiography.

Detailed description

In part I, 60 healthy young subjects free from cardiovascular disease will be examined. In part II, 50 patients with impaired diastolic but preserved systolic function, i.e., patients with arterial hypertension and ejection fraction \> 50%. Doppler echocardiography will be performed at baseline before induction of anaesthesia, during anaesthesia in the spontaneously breathing patient, and in the mechanically ventilated patient.

Conditions

• Young Healthy Adults
• Ventricular Dysfunction

Interventions

Type	Name	Description
DRUG	TTE measurements under anesthesia with sevoflurane, isoflurane, desflurane, and remifentanyl	TTE measurements were performed during remifentanil 2 ng/ml TCI end-organ concentration, 1 MAC of either anesthetic gas under spontaneous ventilation and 1 MAC of either anesthetic under IPPV
DRUG	Sevoflurane, Isoflurane, Desflurane	1 MAC

Timeline

• Start date: 2004-06-01
• Primary completion: 2010-04-01
• Completion: 2010-04-01
• First posted: 2005-10-26
• Last updated: 2010-07-01

Locations

1 site across 1 country: Switzerland