Trials / Completed
CompletedNCT00244400
Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (planned)
- Sponsor
- Osaka City University · Academic / Other
- Sex
- All
- Age
- 14 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.
Detailed description
Femur head necrosis is one of the major side effects of corticosteroid therapy. Since corticosteroids are metabolized by hepatic cytochrome P-450 (CYP) 3A, a low endogenous activity of this enzyme may contribute to the pathogenesis of ONFH. The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.
Conditions
Timeline
- Start date
- 2002-11-01
- Completion
- 2006-01-01
- First posted
- 2005-10-26
- Last updated
- 2006-10-17
Locations
1 site across 1 country: Japan
Source: ClinicalTrials.gov record NCT00244400. Inclusion in this directory is not an endorsement.