NCT00241592

Vaporization as a Smokeless Cannabis Delivery System

Vaporization as a Smokeless Cannabis Delivery System: A Pilot Study

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 18 (planned)
• Sponsor: Center for Medicinal Cannabis Research · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

A study to evaluate the use of a vaporization system as a smokeless delivery system for inhaled marijuana.

Detailed description

Our primary objective is to evaluate the use of a vaporization system ( the Volcano) as a smokeless delivery system for inhaled marijuana. We will compare plasma levels of delta-9-tetrahydrocannabinol (THC), cannabinol, cannabidiol, and metabolites, including 11-OH-THC, in healthy volunteers after smoking \~400 mg each of approximately 1.8, 3.5, and 7% THC marijuana cigarettes (using the Foltin puff procedure) to those obtained when the same individuals inhale the vaporization product of the rest of the marijuana from the identical cigarette processed through the Volcano device. In addition to plasma levels, we will also compare the THC concentrations over an 8-hour time period, the subjective high experienced by the patients, and clinical evidence of cannabis effect by evaluating conjunctival hyperemia and heart rate. We will also compare the tolerability of the two methods of ingestion, and we will monitor expired carbon monoxide to evaluate whether the vaporizer reduces exposure to respiratory toxins.

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
DRUG	Cannabis

Timeline

• Start date: 2004-08-01
• Completion: 2005-05-01
• First posted: 2005-10-19
• Last updated: 2007-06-14

Locations

1 site across 1 country: United States