NCT00237471

Impact of Tight Glycaemic Control in Acute Myocardial Infarction

Impact of Tight Glycaemic Control With Insulin on Novel Vascular Disease Risk Factors and Myocardial Function and Perfusion in Acute Myocardial Infarction Patients With Hyperglycaemia

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (planned)
• Sponsor: Melbourne Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To determine whether tight glycaemic control with insulin improves myocardial function and myocardial perfusion (measured by myocardial contrast echocardiography) and novel vascular risk factors in patients with acute myocardial infarction and hyperglycaemia.

Detailed description

We will randomise patients with acute myocardial infarction and blood glucose levels (BGLs) \>=10mmol/L within 24 hours of pain onset, to either tight glucose control (aiming BGLs 4.5 - 7mmol/L) with an insulin infusion (for 24 hours) followed by subcutaneous insulin or standard control (BGL 6 - 12mmol/L) without the use of an insulin infusion. Serial myocardial contrast echocardiography will measure changes in myocardial perfusion and function from baseline to 3 months between each group. We will also measure changes in inflammatory and endothelial markers over this time to see whether tight glucose control improves these surrogate endpoints.

Conditions

• Myocardial Infarct
• Hyperglycemia

Interventions

Type	Name	Description
DRUG	Insulin (tight blood glucose control)

Timeline

• Start date: 2005-10-01
• Primary completion: 2006-05-01
• Completion: 2006-05-01
• First posted: 2005-10-12
• Last updated: 2011-07-21

Locations

1 site across 1 country: Australia