NCT00232492

Ketamine on Acute Pain in Females and Males

Effect of Racemic Ketamine on Pain in Females and Males After Surgical Removal of Third Molars

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 128 (actual)
• Sponsor: Ullevaal University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 30 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to determine whether equal subanesthetic doses of racemic ketamine is equally effective on females and males after surgical removal of third molars

Detailed description

Ketamine is assumed to be a NMDA receptor antagonist which provides analgesia from acute postoperative pain(and other types of pain) subanesthetic doses. Gender differences in ketamine analgesia are not known. This placebo-controlled,randomised, parallel group study investigates the analgesic dose-response effect of ketamine in subanesthetic doses in female and male patients following surgical removal of third molars. Comparisons: Placebo and ketamine in females and males.

Conditions

• Mouth and Tooth Diseases
• Tooth, Impacted

Interventions

Type	Name	Description
DRUG	Placebo males	Intravenous saline bolus (Placebo-control) males
DRUG	Ketamine 0,1 mg/kg males	0,1 mg/kg ketamine iv bolus males
DRUG	Ketamine 0,3 mg/kg males	0,3 mg/kg ketamine iv bolus males
DRUG	Ketamine 0,5 mg/kg males	0,5 mg/kg ketamine iv bolus males
DRUG	Placebo females	Intravenous saline bolus (Placebo-control) females
DRUG	Ketamine 0,1 mg/kg females	0,1 mg/kg iv bolus ketamine females
DRUG	Ketamine 0,3 mg/kg females	0,3 mg/kg iv bolus ketamine females
DRUG	Ketamine 0,5 mg/kg females	0,5 mg/kg iv bolus ketamine females

Timeline

• Start date: 2005-01-01
• Primary completion: 2006-11-01
• Completion: 2006-11-01
• First posted: 2005-10-04
• Last updated: 2011-07-06

Locations

1 site across 1 country: Norway