NCT00223574

Canadian Trial of Dietary Carbohydrates in Diabetes

Long-Term Effect of Altering the Source or Amount of Dietary Carbohydrate in Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 168 (planned)
• Sponsor: University of Toronto · Academic / Other
• Sex: All
• Age: 35 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

A long-term low carbohydrate, high monounsaturated fat diet, compared to a high carbohydrate, low glycemic index diet, results in more rapid progression of diabetes; i.e. increased fasting glucose and glycated hemoglobin, reduced beta-cell function and insulin sensitivity and increased free fatty acids. The deleterious effects of a high carbohydrate diet on plasma lipids are only temporary and do not persist beyond 6 months. A long-term high carbohydrate, low glycemic index diet, compared to a high carbohydrate, high glycemic index diet, improves glycemic control and beta-cell function

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
DRUG	Control - high carbohydrate, high glycemic index foods
DRUG	high carbohydrate, low glycemic index foods
DRUG	low carbohydrate, high monounsaturate fat foods

Timeline

• Start date: 2002-01-01
• Completion: 2004-10-01
• First posted: 2005-09-22
• Last updated: 2005-09-22

Locations

5 sites across 1 country: Canada