NCT00221780

Role of Left Ventricular Pacing Site

Importance of Left Ventricular Pacing Site in Biventricular Resynchronization Therapy for Severe Heart Failure

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (estimated)
• Sponsor: University Hospital, Bordeaux · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site. We study in a random order 11 different left ventricular pacing sites and compare their hemodynamics using pressure-volume catheters. The consequences on the surface ECG are also assessed.

Detailed description

Background. Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site. Design. Single-blind, monocentric, randomized cross-over study comparing 11 left ventricular pacing sites in a random order. Intervention. Left ventricular DDD pacing on 11 ventricular sites, prior to the implantation. At each pacing site, a control hemodynamics will be obtained in AAI pacing at the same pacing rate. At each pacing site, 2 AV delays, a short and a long one, will be assessed. Eligibility criteria. Patients referred for cardiac resynchronization therapy for heart failure Outcomes. Hemodynamic measures using pressure-volume catheters.

Conditions

• Heart Failure
• Cardiomyopathy, Dilated
• Coronary Disease

Interventions

Type	Name	Description
DEVICE	left ventricular pacing

Timeline

• Start date: 2003-11-01
• Completion: 2007-12-01
• First posted: 2005-09-22
• Last updated: 2007-06-29

Locations

1 site across 1 country: France