NCT00220896

Prevention of Postoperative Delirium With Donepezil

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: Technical University of Munich · Academic / Other
• Sex: All
• Age: 70 Years
• Healthy volunteers: Not accepted

Summary

Patients undergoing hip or knee joint replacement at the age of 70 years or above who are cognitively unimpaired will receive donepezil or matching placebo before (over 5-7 days), during and after (over 7 days) surgery. The incidence of delirium will be monitored at 3 days, 7 days, and 49 days following surgery. We hypothesize that the incidence of delirium can be lowered from 20 per cent to 10 per cent by the intervention.

Conditions

• Cognitively Normal Elderly Individuals

Interventions

Type	Name	Description
DRUG	Donepezil

Timeline

• Start date: 2006-01-01
• Completion: 2009-03-01
• First posted: 2005-09-22
• Last updated: 2011-09-14

Locations

1 site across 1 country: Germany