NCT00218933

High-intensity Exercise Training in Patients With Post-infarction Heart Failure

Anti-remodeling Effect of High-intensity Interval Training in Patients With Post-infarction Heart Failure on Optimal Treatment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: Norwegian University of Science and Technology · Academic / Other
• Sex: All
• Age: 30 Years
• Healthy volunteers: Not accepted

Summary

Introduction: Moderate-intensity endurance-training is known to reduce symptoms, increase exercise tolerance, and improve quality of life in patients with chronic heart failure. The training benefits have mainly been attributed to adaptations in the peripheral circulation and skeletal muscle rather than to adaptations in cardiac performance. However attenuation of left ventricular (LV) remodelling has been documented in some studies. The effects of high- vs. moderate exercise-intensity on LV-remodelling and endothelial function in patients with post-infarction heart failure are not definitively established and were studied in the present study. Methods: Patients with post-infarction heart failure (45-87 yrs, 22-males, 5-females, all received b-blockers and ACE-inhibitors, EF 29%, peak oxygen uptake 13 ml/kg/min) were randomized to 12-weeks, 2-3 times per week, of either moderate exercise-intensity (70% of peak heart rate), high-intensity interval-training (95% of peak heart rate) or to a control group that received advise from their regular doctors. Patients in the two exercise-groups covered similar distance on the treadmill at each exercise-session so that only exercise-intensity differed; i.e. the duration of exercise was longer in the moderate-intensity group. Ultrasound was used to assess LV-dimension and function (including Tissue Doppler Imaging, TDI) and endothelial function in the brachial-artery.

Conditions

• Heart Failure
• Myocardial Infarction

Interventions

Type	Name	Description
BEHAVIORAL	Moderate intensity exercise training	12-weeks, 2-3 times per week moderate exercise-intensity (70% of peak heart rate)
BEHAVIORAL	High intensity exercise training	12-weeks, 2-3 times per week high-intensity interval-training (95% of peak heart rate)

Timeline

• Start date: 2001-10-01
• Primary completion: 2005-09-01
• Completion: 2005-09-01
• First posted: 2005-09-22
• Last updated: 2017-02-09

Locations

1 site across 1 country: Norway