NCT00216944

Balanced Anesthesia for Intubation of Premature Infants

Balanced Anesthesia for Intubation of Newborn Premature Infants - a Randomized Intervention Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Lund University Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The study aim is to compare a balanced anesthesia of the medicines used in all other age groups with the routine premedication in use for premature's with regards to the success in the intubation procedure, the need for analgesia during and after intubation and the stress reaction. In addition a pain scale for prolonged stress/pain for premature neonates in NICU-care will be validated, and the individual pharmacogenetic profile in relation to the need of morphine after the intubation will be investigated. The hypothesis is that balanced anesthesia before intubation facilitates the procedure, decreases the amount of stress and pain related to it, and causes a decreased need for analgesia after the intubation.

Conditions

• Premature Birth

Interventions

Type	Name	Description
PROCEDURE	Tracheal intubation for respiratory care in preterm infants	Premedication with atropine 0.02 mg/kg and morphine 0.03 mg/kg
PROCEDURE	Tracheal intubation for respiratory care in preterm infants	Premedication with glycopyrronium 0.005 mg/kg, thiopental 2-3 mg/kg (\< 2 kg 2 mg/kg), suxamethonium 2 mg/kg and remifentanil 0.001 mg/kg

Timeline

• Start date: 2005-08-01
• Primary completion: 2009-10-01
• Completion: 2009-10-01
• First posted: 2005-09-22
• Last updated: 2010-02-15

Locations

1 site across 1 country: Sweden